Promoter for introducing a gene into a lymphocyte or blood cell and application thereof
AssigneeThe Research Foundation for Microbial Diseases of Osaka University
InventorsMasaya Takemoto, Yasuko Mori, Koichi Yamanishi, Isao Fuke, Yasuyuki Gomi, Michiaki Takahashi
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Abstract
It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In the invention, the object was achieved by finding that HHV6 MIE promoter, HHV7 MIE promoter and HHV7 U95 promoter unexpectedly induce a specific expression in an immunocompetent cell and/or a blood cell such as a T lymphocyte. By utilizing the promoters, a selective delivery of a DNA vaccine or the like can be realized.
Claims18
An isolated nucleic acid comprising an MIE promoter of HHV6B, comprising the sequence set forth in SEQ ID NO:
- 1, wherein the nucleic acid has promoter activity.
Dependencies are inferred from the claim text.