SSX-4 peptides presented by HLA class II molecules
AssigneeLudwig Institute for Cancer Research
InventorsDanila Valmori, Maha Ayyoub
Life of this patent
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Abstract
The invention describes HLA class II binding peptides encoded by the SSX-4 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-4 gene.
Claims11
An isolated nucleic acid molecule encoding an SSX-4 HLA class II-binding peptide, wherein the HLA class II-binding peptide comprises the amino acid sequence selected from the group consisting of SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, and SEQ ID NO:9, and wherein the HLA class II-binding peptide does not include a full length SSX-4 protein as provided in SEQ ID NO:
- 1 or SEQ ID NO:
- 3.
An isolated nucleic acid molecule encoding an SSX-4 HLA class II-binding peptide, wherein the HLA class II-binding comprises the amino acid sequence of SEQ ID NO:10, and wherein the HLA class II-binding peptide comprises up to 188 amino acid residues and does not include (i) a full length SSX-4 protein as provided in SEQ ID NO:
- 1 or SEQ ID NO:
- 3, or (ii) a full-length SSX-7 protein.
Dependencies are inferred from the claim text.