Fatty acid phenolic conjugates
AssigneeIndiana University Health, Inc.
InventorsGary P. Zaloga, Rafat Siddiqui, William Stillwell
Life of this patent
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Abstract
This invention relates to a biologically active formulation containing a conjugate of a fatty acid and a complex phenol. The fatty acid can be selected from a variety of fatty acids including acids have between 12 and 24 carbon atoms. The phenol can be a polynuclear phenol, a polyphenol or a polyfunctional phenol having a variety of substituents. The formulation can include pharmaceutically acceptable carrier, including diluent. The formulation can be provided in an active dosage form suitable to inhibit mammalian cell growth and/or metastasis of malignant cells. The formulation can be used to induce cytotoxicity in mammalian cells particularly tumor cells or to treat and prevent cellular injury or dysfunction.
Claims17
A method of treating mammalian cells, the method comprising administering to the cells a pharmaceutical formulation comprising a phenolic ester of a fatty acid in an amount effective to induce cytotoxicity in at least a portion of the cells.
A method of treating mammalian cells, the method comprising:
- administering to the cells a pharmaceutical formulation comprising a phenolic ester of a fatty acid in an amount effective to modulate cell injury or cell dysfunction or both.
A method of inhibiting metastasis of malignant tumor cells or a malignant growth in a mammal, said method comprising administering to the mammal a pharmaceutical formulation comprising an effective amount of a phenolic ester of a fatty acid in a pharmaceutically acceptable carrier to inhibit the tumor cell or malignant growth from metastasizing to a secondary tissue site.
A method of treating mammalian cells, the method comprising administering to the cells a pharmaceutical formulation comprising a histidyl conjugate of a fatty acid in an amount effective to modulate cell injury or cell dysfunction or both.
Dependencies are inferred from the claim text.