Phosphorylated Ndr kinase
AssigneeNovartis Forschungesstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
InventorsSamuel Joseph Bichsel, Brian Arthur Hemmings, Mario Reinhard Stegert, Rastislav Tamaskovic
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Abstract
The present invention relates to the phosphorylated form of nuclear serine/threonine protein kinase, designated nuclear, Dbf2-related kinase (Ndr), and provides assays and materials for identifying modulators thereof. The invention relates to the fields of molecular biology, chemistry, pharmacology, and screening technology.
Claims2
An isolated antibody that specifically binds to a polypeptide, wherein the polypeptide is nuclear, Dbf-2 related (Ndr) phosphokinase having the amino acid sequence of SEQ ID NO:2, wherein the polypeptide is phosphorylated at amino acid Thr-74, or the polypeptide has the amino acid Thr-74 replaced by an acidic amino acid residue;
- and wherein the antibody recognizes an epitope comprising the phosphorylated amino acid, the epitope comprising a S100 binding region encompassing amino acids 62-83.
Dependencies are inferred from the claim text.