Auto-antibodies against the melanocortin-4 receptor
AssigneeUniversity of Basel
InventorsKarl Hofbauer, Jean-Christophe Peter
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Abstract
Disclosed are biological markers for obesity and methods for diagnosing and treating obesity and related conditions by detecting and modulating the activity of auto-antibodies against the melanocortin-4 receptor or a portion of the melanocortin-4 receptor. Also disclosed are methods for discovering new therapeutics which modulate the activity of auto-antibodies against the melanocortin-4 receptor or a portion of the melanocortin-4 receptor, in particular which prevent the binding of auto-antibodies against the melanocortin-4 receptor or a portion of the melanocortin-4 receptor.
Claims7
A biological marker comprising an isolated auto-antibody or fragment thereof that binds to melanocortin-4-receptor or a portion of the melanocortin-4-receptor, wherein said auto-antibody or fragment thereof binds to a portion of the melanocortin-4 receptor comprising SEQ ID NO:2.
Dependencies are inferred from the claim text.