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AssigneeMedImmune, LLC
InventorsWilliam Dall'Acqua, Herren Wu, Melissa Damschroder, Jose Casa-Finet
Estimating the term…
The present invention relates to novel molecules (Fc variants) comprising at least one antigen binding region and an Fc region that further comprises a modified hinge which alters the binding of Fc to one or more Fc ligand (e.g., FcγRs) and/or modulates effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more FcγR and/or CIq. Additionally, the Fc variants have altered antibody-dependent cell-mediated cytotoxicity (ADCC) and/or complement dependent cytotoxicity (CDC) activity. The invention further provides methods and protocols for the application of said Fc variants particularly for therapeutic purposes.
A polypeptide comprising an Fc region, said Fc region comprising a modified IgG1 hinge region, wherein said Fc region binds C1q with an increased affinity relative to a polypeptide having the same amino acid sequence except having a wild type hinge, and wherein the modified hinge region comprises the amino acid substitution C233D (not EU number, Kabat number) utilizing the Kabat numbering system set forth in Kabat.
A polypeptide comprising an Fc region, said Fc region comprising a modified IgG1 hinge region, wherein said Fc region binds C1q with an increased affinity relative to a polypeptide having the same amino acid sequence except having a wild type hinge, and wherein the modified hinge region comprises a set of amino acid substitutions selected from the group consisting of:
Dependencies are inferred from the claim text.