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US 8,008,353 B2Granted
Methods for modulating macrophage proliferation using polyamine analogs
AssigneeThe Regents of the University of California
InventorMichael S. McGrath
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AssigneeThe Regents of the University of California
InventorMichael S. McGrath
Estimating the term…
Methods for modulating macrophage proliferation in an individual afflicted with or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a number of serious disorders, including AIDS (HIV)-associated dementia, AIDS-associated non-Hodgkin's lymphoma, and Alzheimer's disease. The invention also provides methods for aiding diagnosis and monitoring therapy of a macrophage-associated non-HIV associated dementia, especially Alzheimer's disease. The invention also provides methods of delaying development of macrophage-associated non-HIV associated dementias, including Alzheimer's disease, which entail administration of an agent which modulates macrophage proliferation.
A method of treating a subject afflicted with, or at risk for, HIV-associated dementia or delaying development or onset of HIV-associated dementia in said subject comprising administering to said subject effective amount of a composition comprising mitoguazone or a salt of mitoguazone, wherein the patient does not have AIDS-related non-Hodgkin's lymphoma.
A method of modulating macrophage proliferation in an individual afflicted with, or at risk for, HIV-associated dementia comprising administering to the individual an effective amount of a composition comprising mitoguazone or a salt of mitoguazone, wherein the patient does not have AIDS-related non-Hodgkin's lymphoma.
A method of modulating macrophage proliferation in an individual afflicted with, or at risk for, a macrophage-associated disease comprising administering to the individual an effective amount of a composition comprising mitoguazone or a salt of mitoguazone, wherein the disease is HIV-associated dementia or non-HIV-associated dementia, wherein the patient does not have AIDS-related non-Hodgkin's lymphoma.
A method of treating a subject afflicted with, or at risk for, a macrophage-associated disease or delaying onset or development of a macrophage-associated disease in said subject comprising administering to said subject an effective amount of a composition comprising mitoguazone or a salt of mitoguazone to reduce macrophage proliferation in said subject, wherein the disease is HIV-associated dementia or non-HIV-associated dementia, wherein the patient does not have AIDS-related non-Hodgkin's lymphoma.
Dependencies are inferred from the claim text.