Methods for prophylaxis or treatment of conditions associated with cortical spreading depression
AssigneeUCB Pharma S.A.
InventorsDieter Scheller, Thomas Stöhr
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Abstract
The present invention is directed to the use of a class of peptide compounds for the prophylaxis and treatment of chronic headache, particularly migraines.
Claims29
A method for treating a condition associated with cortical spreading depression (CSD) in a subject, comprising administering to the subject, in an amount effective to suppress CSD, a compound having the Formula (IIb)
- wherein
- Ar is phenyl which is unsubstituted or substituted with at least one halo group;
- R3 is CH2-Q, wherein Q is lower alkoxy containing 1-3 carbon atoms;
- and
- R1 is lower alkyl containing 1-3 carbon atoms,
- or a pharmaceutically acceptable salt thereof, wherein the condition associated with CSD is a chronic headache selected from a group consisting of a muscle contraction headache, a toxic headache, a cluster headache, a traction headache, and an inflammatory headache.
A method of suppressing CSD to prevent or treat a CSD-initiated headache in a subject in need thereof, the CSD-initiated headache selected from the group consisting of a muscle contraction headache, a toxic headache, a cluster headache, a traction headache, and an inflammatory headache, the method comprising administering to the subject an oral effective amount of (R)-2-acetamido-N-benzyl-3-methoxypropionamide.
A method of treating in a subject a CSD-associated condition selected from the group consisting of a head injury, transient global amnesia, and intracranial hemorrhage, the method comprising administering to the subject an effective amount of (R)-2-acetamido-N-benzyl-3-methoxypropionamide.
Dependencies are inferred from the claim text.