Pharmaceutically active benzsulfonamide derivatives as inhibitors of protein junkinases

A benzsulfonamide according to formula I

• its geometrical isomers, in an optically active form as enantiomers, diastereomers, racemates, or pharmaceutically acceptable salts thereof, wherein
• Ar1 is selected from the group consisting of an unsubstituted aryl group, an unsubstituted heteroaryl group, a substituted aryl group, and a substituted heteroaryl group;
• R1 is hydrogen or a C1-C6-alkyl group;
• R2 is hydrogen, —COOR3, —CONR3R3′, OH, a C1-C4 alkyl substituted with an OH group, a hydrazido carbonyl group, a sulfate, a sulfonate, an amine or an ammonium salt;
• n is either 0 or 1;
• Y is a pyrrolidinyl group represented by the following formula:
• whereby, L1 is selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C4-C8-cycloalkyl optionally containing 1-3 heteroatoms and optionally fused with aryl or heteroaryl, aryl, heteroaryl, aryl-C1-C6-alkyl, heteroaryl-C1-C6-alkyl, —C(O)—OR3, —C(O)—R3, —C(O)—NR3′R3, —NR3′R3, —NR3′C(O)R3, —NR3′C(O)NR3′R3, —(SO)R3, —(SO2)R3, —NHSO2R3, and —SO2NR3′R3,
• with R3, R3′ being substituents independently selected from the group consisting of H, C1-C6-alkyl, C2-C6-alkenyl, aryl, heteroaryl, aryl-C1-C6-alkyl, and heteroaryl-C1-C6-alkyl;
• and
• R6 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-alkoxy, OH, halogen, nitro, cyano, sulfonyl, and oxo (═O), and
• n′ is an integer from 0 to 4.