Bis-heterocyclic imidazolyl compounds

Compound of the general formula

• in which
• (A) R1 is phenyl or pyridyl if R, R2, R3 and R4 are hydrogen and n is 0, whereby phenyl or pyridyl is substituted by 1-4 C1-C8-alkoxy, C1-C8-alkoxycarbonyl, C1-C8-alkyl, C0-C8-alkylcarbonyl, C1-C8-alkylsulphonyl, unsubstituted or substituted aryl, aryl-C0-C4-alkoxycarbonyl, cyano, halogen, unsubstituted or substituted heterocyclyl, hydroxyl, tri-C1-C4-alkylsilyl, trifluoromethoxy or trifluoromethyl, at least one substituent being located in the “para” position (relative to the 6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl ring system);
• or
• (C) R1 is aryl or unsaturated heterocyclyl, which radicals are substituted by 1-4 C1-C8-alkoxy, C1-C8-alkoxycarbonyl, C1-C8-alkyl, C0-C8-alkylcarbonyl, C1-C8-alkylsulphanyl, C1-C8-alkylsulphonyl, unsubstituted or substituted aryl, aryl-C0-C4-alkoxycarbonyl, cyano, halogen, unsubstituted or substituted heterocyclyl, hydroxyl, nitro, oxide, oxo, tri-C1-C4-alkylsilyl, trifluoromethoxy or trifluoromethyl, at least one substituent being C1-C8-alkylsulphanyl, hydroxyl, nitro or oxide;
• or
• (D) R1 is aryl or unsaturated heterocyclyl if R3 and R4 are both not simultaneously deuterium or hydrogen, whereby aryl or unsaturated heterocyclyl is substituted by 1-4 C1-C8-alkoxy, C1-C8-alkoxycarbonyl, C1-C8-alkyl, C0-C8-alkylcarbonyl, C1-C8-alkylsulphonyl, unsubstituted or substituted aryl, aryl-C0-C4-alkoxycarbonyl, cyano, halogen, unsubstituted or substituted heterocyclyl, oxo, tri-C1-C4-alkylsilyl, trifluoromethoxy or trifluoromethyl;
• or
• (E) R1 is aryl or unsaturated heterocyclyl if R2 is hydroxyl or C1-C8-alkoxy, whereby aryl or unsaturated heterocyclyl is substituted by 1-4 C1-C8-alkoxy, C1-C8-alkoxycarbonyl, C1-C8-alkyl, C0-C8-alkylcarbonyl, C1-C8-alkylsulphonyl, unsubstituted or substituted aryl, aryl-C0-C4-alkoxycarbonyl, cyano, halogen, unsubstituted or substituted heterocyclyl, oxo, tri-C1-C4-alkylsilyl, trifluoromethoxy or trifluoromethyl;
• R a) is deuterium, halogen, tri-C1-C4-alkylsilyl, trifluoromethoxy, trifluoromethyl or hydrogen;
• or
• b) is C1-C8-alkoxy or C1-C8-alkyl;
• R2 a) is deuterium, halogen, hydroxyl or hydrogen;
• or
• b) is C2-C8-alkenyl, C2-C8-alkynyl, C1-C8-alkoxy, C1-C4-alkoxycarbonyl-C1-C4-alkyl, C1-C8-alkyl, C0-C4-alkylcarbonyl, aryl-C0-C4-alkyl, carboxy-C1-C4-alkyl, C3-C8-cycloalkyl or unsaturated heterocyclyl-C0-C4-alkyl, which radicals may be substituted by 1-4 C1-C8-alkoxy, C1-C9-alkoxycarbonyl, C1-C8-alkyl, C0-C8-alkylcarbonyl, C1-C8-alkylsulphonyl, unsubstituted or substituted aryl, aryl-C0-C4-alkoxycarbonyl, cyano, halogen, unsubstituted or substituted heterocyclyl, hydroxyl, nitro, oxide, oxo, tri-C1-C4-alkylsilyl, trifluoromethoxy or trifluoromethyl;
• R3 a) is deuterium, halogen, hydroxyl, trifluoromethoxy, trifluoromethyl or hydrogen;
• or
• b) is C1-C8-alkoxy or C1-C8-alkyl;
• R4 a) is deuterium, halogen, trifluoromethoxy, trifluoromethyl or hydrogen;
• or
• b) is C1-C8-alkoxy or C1-C8-alkyl;
• n is a number 0;
• and salts thereof, preferably pharmaceutically useful salts thereof,
• where,
• if R2 is hydrogen R1 is not carbazolyl, fluorenyl or naphthyl;
• if R is hydrogen and R2 is hydroxyl R1 is not C1-C8-alkoxy- or halobenzothiophen-2-yl, unsubstituted or substituted biphenyl or 4-bromophenyl.