Indole derivatives and their use as medicament

Indole compounds of the general Formula 1

• in which
• R denotes hydrogen, straight-chain (C1-C6)-alkyl or branched (C1-C6)-alkyl;
• R1 denotes a 5-quinolyl, 6-quinolyl or 7-quinolyl group bonded to the amide nitrogen directly:
• R2 denotes hydrogen-o2(C1-C6)-alkyl, or (C1-C6)-alkyl which is mono- or polysubstituted by phenyl, where the phenyl radical may be unsubstituted or mono- to pentasubstituted by identical or different substituents from the group consisting of halogen, preferably chlorine, bromine or iodine;
• R3 and R4 may be attached to the indole carbon atoms C-2, C-4, C5, C-6 or C-7 and independently of one another denote hydrogen, hydroxyl, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, (C1-C6)-alkylcarbonyl, (C1-C6)-alkoxy, halogen, aryl-(C1-C4)-alkoxy, nitro, amino, mono-(C1-C4)-alkylamino, di-(C1-C4)-alkylamino, (C1-C6)-alkoxycarbonylamino, (C1-C6)-alkoxycarbonylamino-(C1-C6)-alkyl, cyano, straight-chain or branched cyano-(C1-C6)-alkyl, carboxyl, (C1-C4)-alkoxycarbonyl, (C1-C4)-alkyl which is substituted by one or more fluorine atoms, carboxy-(C1-C6)-alkyl or (C1-C6)-alkoxycarbonyl-(C1-C6)-alkyl;
• Z1 denotes oxygen or sulfur;
• Z2 denotes oxygen or sulfur.