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US 8,008,311 B2Granted
Methods and compostions utilizing quinazolinones
AssigneeCytokinetics, Inc.
InventorsJeffrey T. Finer, Gustave Bergnes, Bainian Feng, Whitney W. Smith, John C. Chabala
Life of this patent
Estimating the term…
Abstract
Quinazolinones of formulae (a, b, c and d) are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
Claims4
A method for disrupting mitosis in a cell, comprising administering to the cell an effective amount of a compound having the formula
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is benzyl;
- R2 is i-propyl;
- R2 is hydrogen;
- R3 is p-methylphenyl;
- R4 is 3-amino-n-propyl;
- R5 is hydrogen;
- R6 is hydrogen;
- R7 is chloro;
- and
- R8 is hydrogen.
8 more elements
A method for disrupting mitosis in a cell, comprising administering to the cell an effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound having the formula
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is benzyl;
- R2 is i-propyl;
- R2′ is hydrogen;
- R3 is p-methylphenyl;
- R4 is 3-amino-n-propyl;
- R5 is hydrogen;
- R6 is hydrogen;
- R7 is chloro;
- and
- R8 is hydrogen.
8 more elements
Dependencies are inferred from the claim text.