Quinoline compounds
AssigneeKowa Company, Ltd.
InventorsMinoru Koura, Ayumu Okuda, Takayuki Matsuda, Yuki Yamaguchi, Hisashi Sumida, Sayaka Kurobuchi, Yuichiro Watanabe, Takashi Enomoto, Kimiyuki Shibuya
Life of this patent
Estimating the term…
Abstract
To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. A quinoline compound represented by the following general formula (1) or salt thereof, or their solvate.
Claims11
A quinoline compound represented by the following general formula (1) or salt thereof:
- (wherein R1 represents a hydrogen atom, halogen atom, C1-8 alkyl group, C3-8 cycloalkyl group, C2-8 alkenyl group, C3-8 cycloalkenyl group, C3-8 cycloalkenyl-C1-8 alkyl group, C1-8 alkoxy group, C6-10 aryl group, C6-10 aryl C1-8 alkyl group, C6-10 aryl C2-6 alkenyl group, C1-8 acyl group, C6-10 arylcarbonyl group, C1-8 alkylthio group, C1-8 alkylsulfinyl group, C1-8 alkylsulfonyl group, C6-10 arylsulfonyl group, nitro group, amino group, mono C1-8 alkylamino group, di C1-8 alkylamino group, C3-8 cycloalkyl C1-8 alkyl group, C3-8 cycloalkyl C2-8 alkenyl group, C3-8 cycloalkyl C2-8 alkynyl group, halo C1-8 alkyl group, or cyano group, wherein the C6-10 aryl may be substituted with 1 to 3 same or different substituents selected from the following group A;
- R2 represents a hydrogen atom, C1-8 alkyl group, halo C1-8 alkyl group, or halogen atom;
- R3, R4, R5, and R6 each independently represents a hydrogen atom, halogen atom, or C1-8 alkyl group;
- R7 and R8 each independently represents a hydrogen atom, C1-8 alkyl group, C3-8 cycloalkyl group, C3-8 cycloalkyl C1-8 alkyl group, C6-10 aryl group, or 5- to 11-membered heterocyclic group, wherein the C6-10 aryl and 5- to 11-membered heterocycle may be substituted with 1 to 3 same or different substituents selected from the following group A, or R7 and R8 may together form a 5- to 7-membered carbocycle;
- R9 represents a hydrogen atom, C1-8 alkyl group, halo C1-6 alkyl group,
- C3-8 cycloalkyl group, or C3-8 cycloalkyl C1-8 alkyl group;
- X represents a bond or a C1-8 alkyl chain, C6-10 aryl chain, or 5- to 11-membered heteroaryl chain;
- Y represents a —O—, —S—, or —N(R10)—;
- R10 represents a hydrogen atom or C1-8 alkyl group;
- and L represents a C1-8 alkyl chain or C2-8 alkenyl chain),
- [Group A:
- halogen atom, C1-8 alkyl group, halo C1-8 alkyl group, C2-8 alkenyl group, C2-8 alkynyl group, C3-8 cycloalkyl group, cyano group, nitro group, hydroxy group, amino group, mono C1-8 alkylamino group, di C1-8 alkylamino group, C1-8 alkoxy group, halo C1-8 alkoxy group, C1-8 acyl group, carboxyl group, C1-8 acyloxy group, C1-8 alkoxycarbonyl group, carbamoyl group, C6-10 aryl group, 5- to 11-membered heteroaryl group, C6-10 aryl C1-8 alkoxy group, C1-8 alkylthio group, C1-8 alkylsulfinyl group, C1-8 alkylsulfonyl group, C6-10 arylthio group, C6-10 arylsulfinyl group, and C6-10 arylsulfonyl group].
Dependencies are inferred from the claim text.