Back to results
US 8,008,283 B2Granted
Methods and compositions for the treatment of neuropsychiatric disorders
AssigneeNeuroTherapeutics Pharma, Inc.
InventorsDaryl W. Hochman, John J. Partridge
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods and compositions for treating neuropathic pain and neuropsychiatric disorders by administering agents that are effective in reducing the effective amount, inactivating, and/or inhibiting the activity of a Na+—K+-2Cl− (NKCC) cotransporter. In certain embodiments, the Na+—K+-2Cl− co-transporter is NKCC1.
Claims5
A compound of formula I:
- or a pharmaceutically acceptable salt or tautomer thereof, wherein
- R1 is not present, or O;
- when R1 is O, R2 is selected from the group consisting of:
- alkyloxycarbonylalkyl and alkylamide unsubstituted or substituted with alkyl, acyl, alkenyl, alkynyl cycloalkyl, aryl, hydroxy, alkoxy, aryloxy, acyl, amino, amido, carboxy, carboxyalkyl, carboxyaryl, halo, oxo, mercapto, sulfinyl, sulfonyl, sulfonamido, amidino, carbamoyl, dialkoxymethyl, cycloalkyl, heterocycloalkyl, dialkylaminoalkyl, carboxylic acid, carboxamido, haloalkyl, alkylthio, aralkyl, alkylsulfonyl, arylthio, amino, alkylamino, dialkylamino, guanidino, or ureido, and when R1 is not present, R2 is selected from the group consisting of dialkylamino and diarylalkylamino, unsubstituted or substituted with alkyl, acyl, alkenyl, alkynyl cycloalkyl, aryl, hydroxy, alkoxy, aryloxy, acyl, amino, amido, carboxy, carboxyalkyl, carboxyaryl, halo, oxo, mercapto, sulfinyl, sulfonyl, sulfonamido, amidino, carbamoyl, dialkoxymethyl, cycloalkyl, heterocycloalkyl, dialkylaminoalkyl, carboxylic acid, carboxamido, haloalkyl, alkylthio, aralkyl, alkylsulfonyl, arylthio, amino, alkylamino, dialkylamino, guanidino, or ureido;
- R3 is selected from the group consisting of aryl, halo, hydroxy, alkoxy, and aryloxy, unsubstituted or substituted with alkyl, acyl, alkenyl, alkynyl cycloalkyl, aryl, hydroxy, alkoxy, aryloxy, acyl, amino, amido, carboxy, carboxyalkyl, carboxyaryl, halo, oxo, mercapto, sulfinyl, sulfonyl, sulfonamido, amidino, carbamoyl, dialkoxymethyl, cycloalkyl, heterocycloalkyl, dialkylaminoalkyl, carboxylic acid, carboxamido, haloalkyl, alkylthio, aralkyl, alkylsulfonyl, arylthio, amino, alkylamino, dialkylamino, guanidino, or ureido;
- and
- R4 and R5 are each independently selected from the group consisting of hydrogen, alkylaminodialkyl, alkylhydroxyaminodialkyl, unsubstituted or substituted with alkyl, acyl, alkenyl, alkynyl cycloalkyl, aryl, hydroxy, alkoxy, aryloxy, acyl, amino, amido, carboxy, carboxyalkyl, carboxyaryl, halo, oxo, mercapto, sulfinyl, sulfonyl, sulfonamido, amidino, carbamoyl, dialkoxymethyl, cycloalkyl, heterocycloalkyl, dialkylaminoalkyl, carboxylic acid, carboxamido, haloalkyl, alkylthio, aralkyl, alkylsulfonyl, arylthio, amino, alkylamino, dialkylamino, guanidino, or ureido.
4 more elements
A compound which is bumetanide benzyl ester, bumetanide morpholinoethyl ester;
- bumetanide 3-(dimethylaminopropyl) ester;
- bumetanide N,N-diethylglycolamide ester;
- bumetanide dimethylglycolamide ester;
- bumetanide pivaxetil ester;
- bumetanide propaxetil ester, or pharmaceutically acceptable salts or tautomers thereof.
2 more elements
Dependencies are inferred from the claim text.