Betulinol derivatives as anti-HIV agents
AssigneeBiorings LLC
InventorsBrij B. Saxena, Premila Rathnam
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Abstract
The present invention relates to methods of treating HIV-1 infection in a subject. These methods involve administering to the subject with HIV-1 infection a therapeutically effective amount of a conjugated or immunoconjugated betulinol derivative compound, or a pharmaceutically acceptable salt or derivative thereof, under conditions effective to treat the subject for HIV-1 infection. Also disclosed are methods inhibiting HIV-1 activity in a cell. These methods involve providing a cell infected with HIV-1 and contacting the cell with a conjugated or immunoconjugated betulinol derivative compound, or a pharmaceutically acceptable salt or derivative thereof, under conditions effective to inhibit HIV-1 activity in the cell.
Claims9
A method of treating HIV-1 infection in a subject, said method comprising:
- administering to a subject with HIV-1 infection a therapeutically effective amount of a compound having the formula
- or a pharmaceutically acceptable salt thereof,
- wherein
- R1 is selected from the group consisting of —CH3, ═O, —OH, —OCH3, —OC(O)CH3, —NHNH-2,4-Dinitrophenyl, and ═S and
- R3 is selected from the group consisting of H and C1-C5 alkyl,
- n is an integer from 1 to 12;
- and
- Z is H or a protective group.
Dependencies are inferred from the claim text.