Use of zwitterionic polysaccharides for the specific modulation of immune processes
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsJulia Ying Wang, Michael H. Roehrl, Dennis L. Kasper
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Abstract
The invention relates to three-dimensional molecular structure determination of polymers, three-dimensional computer molecular modeling, rational drug design, and immunomodulatory polymers. In particular the invention is directed to immunomodulatory polymers, as well as to methods for designing, selecting, and screening therapeutic agents having immunomodulatory activity.
Claims21
An isolated immunomodulatory polymer, comprising:
- a polymer comprising a plurality of a repeating unit, with each repeating unit comprising a tetramer backbone having a structure
- -(S1-S2-S3-S4)-
- including, each independent of the others, a first subunit S 1, a second subunit S2, a third subunit S3, and a fourth subunit S4, each tetramer backbone including a negatively charged moiety on the first subunit S1 and a free amino moiety on the fourth subunit S4.
An isolated immunomodulatory polysaccharide, comprising:
- a polysaccharide comprising a plurality of a repeating unit, with each repeating unit comprising a tetrasaccharide backbone having a structure
- -(M1-M2-M3-M4)-
- including, each independent of the others, a first monosaccharide M1, a second monosaccharide M2, a third monosaccharide M3, and a fourth monosaccharide M4, each tetrasaccharide backbone including a negatively charged moiety on the first monosaccharide M1 and a free amino moiety on the fourth monosaccharide M4.
An isolated immunomodulatory polysaccharide comprising PS A2.
An isolated immunomodulatory polymer, comprising:
- a polymer having a plurality of a repeating charge motif, wherein the repeating charge motif is a positive charge and a negative charge arranged along the polymer so that positive charges of consecutive charge motifs are separated by less than about 32 Å, wherein the polymer has a three-dimensional solution conformation in which a majority of the positive charges and the negative charges are solvent-accessible, said three-dimensional solution conformation having a plurality of docking sites, each docking site being about 10 Å wide and about 5 Å deep.
Dependencies are inferred from the claim text.