Fucose containing proteoglycan or acidic glycan and their pharmaceutical use
OwnerGradimir Misevicinventor
Life of this patent
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Abstract
A class of proteoglycans containing fucosylated acidic glycans, e.g., as produced by marine sponges and sea urchin embryos, have been found to stimulate selective proliferation of mammalian natural killer (NK) cells and γδT cells. These compounds are useful as pharmaceuticals, particularly as immunostimulants, e.g., in the treatment of cancer and viral infections.
Claims5
A method for treating a human afflicted with Acquired immunodeficiency Syndrome, comprising the step of administering to said human an active ingredient which is at least one oligosaccharide having a structure selected from the group of the following 33 oligosaccharide structures:
- Structure 1
- 6
- Pyr< >Galβ1-4GlcNAcβ1-3Fuc
- 4
- Structure 2
- structure 3
- structure 4
- (SO3)GlcNAc-Fuc-Fuc
- structure 5
- Fuc-(SO3)GlcNAc-Fuc
- structure 6
- GlcNAc-(SO3)Gal-Fuc
- structure 7
- Gal-(SO3)Gal-GlcNAc-Fuc-Fuc
- structure 8
- Gal-(SO3)Gal-GlcNAc-Fuc-Fuc
- structure 9
- GlcNAc-Fuc-(SO3)Gal-Fuc
- structure 10
- Pyr(4,6)Gal-Gal-Fuc
- structure 11
- Pyr(4,6)Gal-Gal-Fuc-GlcNAc
- structure 12
- structure 13
- structure 14
- structure 15
- structure 16
- structure 17
- structure 18
- Gal-GlcNAc-Fuc(SO3)-GlcNAc-Fuc
- structure 19
- Gal-GlcNAc-Ara(SO3)-GlcNAc-Fuc
- structure 20
- Gal-GalNAc-Fuc(SO3)-GlcNAc-Fuc
- structure 21
- Gal-GalNAc-Fuc(SO3)-GalNAc-Fuc
- structure 22
- Gal-GlcNAc-Fuc(SO3)-GalNAc-Fuc
- structure 23
- Gal-GalNAc-Ara(SO3)-GlcNAc-Fuc
- structure 24
- Gal-GalNAc-Ara(SO3)-GalNAc-Fuc
- structure 25
- Gal-GlcNAc-Ara(SO3)-GalNAc-Fuc
- structure 26
- GlcNAc-Fuc(SO3)-GlcNAc-Fuc-Fuc
- structure 27
- GlcNAc-Ara(SO3)-GlcNAc-Fuc-Fuc
- structure 28
- GalNAc-Fuc(SO3)-GlcNAc-Fuc-Fuc
- structure 29
- GalNAc-Fuc(SO3)-GalNAc-Fuc-Fuc
- structure 30
- GlcNAc-Fuc(SO3)-GalNAc-Fuc-Fuc
- structure 31
- GalNAc-Ara(SO3)-GlcNAc-Fuc-Fuc
- structure 32
- GalNAc-Ara(SO3)-GalNAc-Fuc-Fuc
- structure 33
- GlcNAc-Ara(SO3)-GalNAc-Fuc-Fuc.
A polysaccharide having a structure selected from the group consisting of the following structures:
- Linear Structure
- (1-2-3→1-2-3→1-2-3→1-2-3) n Times repeat
- Branched structure 2
- n Times repeat
- Branched structure 3
- n Times repeat
- Branched structure 4
- n Times repeat
- Branched structure 4
- n Times repeat
- Wherein the number 1 represents
- 4
- Pyr< >Gal
- 6
- monosaccharide, the number 2 represents GlcNA monosaccharide and number 3 represents Fuc monosaccharide, and wherein the molecular weight is less then 1000 kD.
A polysaccharide having a structure selected from the group consisting of the following structures:
- Linear Model
- (1-2-3-4-5→1-2-3-4-5→1-2-3-4-5→1-2-3-4-5 n Times repeat
- Branched Model Type 2
- n Times repeat
- Branched Model Type 3
- n Times repeat
- Branched Model Type 4
- n Times repeat
- Wherein the number 1 represents GalNAc monosaccharide, the number 2 represents Ara(SO3) monosaccharide, number 3 represents GlcNAc monosaccharide, number 4 represents Fuc monosaccharide and number 5 represents Fuc monosaccharide and wherein the molecular weight is less then 1000 kD.
Dependencies are inferred from the claim text.