Back to results
US 8,008,273 B2Granted
SHIP-deficiency to increase megakaryocyte progenitor production
AssigneeUniversity of South Florida
InventorsWilliam G. Kerr, Caroline Desponts, Lia Elena Perez
Life of this patent
Estimating the term…
Abstract
The invention concerns a method for increasing megakaryocyte and megakaryocyte progenitor numbers in vitro or in vivo by suppressing SH2-containing inositol-5-phosphatase (SHIP) function in megakaryocytes or megakaryocyte progenitors expressing the SHIP gene. SHIP function can be suppressed by administering an interfering RNA, or other SHIP inhibitor, to the megakaryocytes or megakaryocyte progenitors in vitro or in vivo.
Claims13
A method for improving haematopoietic recovery in a patient in need thereof, comprising:
- harvesting megakaryocytes or megakaryocyte progenitors from a patient;
- contacting the megakaryocytes or megakaryocyte progenitors with an effective amount of an inhibitor of SH2-containing inositol-5-phosphatase (SHIP) function, thereby expanding the megakaryocytes or megakaryocyte progenitors, wherein the inhibitor of SHIP function is selected from the group consisting of interfering RNA, antisense oligonucleotide, ribozyme, DNAzyme, nucleic acid modifier, PNA, nonstandard nucleic acid, aptamer, decoy, and dominant/negative mutant;
- and
- reinfusing the expanded megakaryocytes or megakaryocyte progenitors into the patient.
1 more element
Dependencies are inferred from the claim text.