Organic compounds and their uses

A compound of the Formula I:

• and pharmaceutically acceptable salts and stereoisomers thereof;
• wherein
• X is absent or selected from NR5a or oxygen;
• i and k are independently selected integers selected from the group consisting of 0, 1, 2, 3 and 4;
• j is an integer selected from the group consisting of 1, 2, 3 and 4, wherein the sum of i+j+k is less than or equal to 5 and greater than or equal to 2 when X is absent and the sum of i+j+k is less than or equal to 4 and greater than or equal to 1 when X is oxygen;
• p is 0, 1, 2 or 3;
• E is OH, NH2, N(H)C1-4alkyl, N(H)C3-6cycloalkyl, —C(O)NH— or —N(H)S(O)2—;
• R1 is absent, hydrogen, C1-4alkyl or C3-6cycloalkyl;
• R2 is C1-4alkyl, haloC1-4alkyl, or C3-6cycloalkylC0-2alkyl;
• R2a is hydrogen, C1-4alkyl, haloC1-4alkyl, or C3-6cycloalkylC0-2alkyl;
• or
• R2 and R2a, taken in combination form a three membered saturated ring, which ring is substituted with zero, one or two substituents independently selected from C1-4alkyl and C2-4alkenyl;
• R3 and R4 are independently selected from the group consisting of C1-6alkyl, C4-7cycloalkyl and C4-7cycloalkyl substituted with a C1-4alkyl residue;
• R5 represents zero to three residues on
• each independently selected at each occurrence from the group consisting of halogen, hydroxy, amino, C1-4alkyl, C3-6cycloalkyl, C1-4alkoxy, mono- and di-C1-4alkylamino, hydroxyC1-4alkyl, and C1-4alkoxyC1-4alkyl;
• R5a is independently selected at each occurrence from the group consisting of hydrogen, C1-4alkyl, haloC1-4alkyl, C3-6cycloalkyl, hydroxyC1-4alkyl, and C1-4alkoxyC1-4alkyl;
• and
• R6 and R7 are independently selected from hydrogen and C1-4alkyl.