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US 8,008,260 B2Granted
Methods of protecting against apoptosis using lipopeptides
AssigneesThe Cleveland Clinic Foundation, Cleveland BioLabs, Inc.
InventorsAlexander Shakhov, Andrei Gudkov
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Abstract
The use of lipopeptides as inducers of NF-κB for the protection of mammals from the effects of apoptosis is described.
Claims9
A compound of the formula:
- wherein,
- R, represents H or —CO—R4,
- R2, R3 and R4 independently are H or optionally substituted C8-C16 aliphatic;
- Z is S or CH2, and
- X is a peptide, wherein the peptide is an amino acid consisting of SEQ ID NO:
- 21.
3 more elements
Dependencies are inferred from the claim text.