Neurotrophin-derived peptide sequences
AssigneeCopenhagen University, Techtrans Unit
InventorsElisabeth Bock, Vladimir Berezin
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Abstract
The present invention relates to peptide sequences capable of stimulating neuronal cell differentiation, neural cell survival and neuronal plasticity associated with memory and learning. The peptide sequences of the invention are derived from the proteins belonging to neurotrophic factors, such as NGF, NT3, NT4/5 and BDNF. The invention also relates to pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of a disease or condition wherein the effects of stimulating neuronal cell differentiation, neuronal cell survival, stimulating neural plasticity associated with learning and memory are beneficial for treatment.
Claims43
A method of stimulating neurite outgrowth or neuronal cell survival which comprises contacting a neuronal cell with an effective amount of (1) a peptide sequence consisting of 10 to 25 contiguous amino acid residues, comprising at least the amino acid motif of the formula
- xp1-D/E-T-xa1-C (motif I), wherein
- xp1 is Y or I, and
- xa1 is K, R, S, or A,
- or (2) a compound which is a multimer consisting of two or more individual peptide sequences, which may be the same or different, according to (1), and optionally at least one linker covalently connecting at least two such individual peptide sequences.
The method of claim wherein the neuronal cell is in a subject.
Dependencies are inferred from the claim text.