Cop 1 for treatment of inflammatory bowel diseases

A method for inhibiting weight loss, inducing weight regain or reducing macroscopic colonic damage in a patient suffering from severe Crohn's disease, comprising administering to said patient by daily injection an amount of an active agent selected from the group consisting of

• i) Copolymer 1 and Copolymer 1-related peptides consisting of random three- or four-amino acid copolymers made up of one amino acid selected from three or four of the following groups:
• (a) lysine and arginine;
• (b) glutamic acid and aspartic acid;
• (c) alanine and glycine;
• and
• (d) tyrosine and tryptophan;
• and
• ii) a Copolymer 1-related peptide having the sequence of any of SEQ ID NOs:
• 1-32,
• in an amount effective for inhibiting weight loss, inducing weight regain or reducing macroscopic colonic damage in the patient.