Combination therapy for treatment of cancer
AssigneeUniversity of Southern California
InventorsFrancis S Markland, Jr., Steven Swenson, Jacek Pinski
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Abstract
The invention relates to compositions and methods for treating diseases. In particular aspects, the invention relates to administering a combination of a disintegrin with a microtubule stabilizing agent useful for treatment of cancer.
Claims59
A method of treating an individual suffering from cancer, said method comprising administering to said individual an effective amount of a disintegrin and at least one microtubule stabilizing agent, wherein said disintegrin is characterized by having an integrin binding loop stabilized by disulfide bonds.
A method of preventing or inhibiting the growth of metastases in an individual suffering from an integrin expressing cancer, said method comprising administering to said individual an effective amount of a disintegrin and at least one microtubule stabilizing agent.
A method of treating an individual suffering from cancer, said method consisting essentially of administering to said individual an effective amount of a disintegrin and at least one microtubule stabilizing agent, wherein said disintegrin is characterized by having an integrin binding loop stabilized by disulfide bonds.
A method of preventing or inhibiting the growth of metastases in an individual suffering from an integrin expressing cancer, said method consisting essentially of administering to said individual an effective amount of a disintegrin and at least one microtubule stabilizing agent.
Dependencies are inferred from the claim text.