US 8,008,251 B2 · Macrocyclic inhibitors of hepatitis C virus

Macrocyclic inhibitors of hepatitis C virus

AssigneesTibotec Pharmaceuticals Ltd., Medivir AB

InventorsKenneth Alan Simmen, Herman Augustinus De Kock, Pierre Jean-Marie Bernard Raboisson, Mats Stefan Lindström, Pia Cecilia Kahnberg, Dmitry Antonov, Karl Magnus Nilsson, Bengt Bertil Samuelsson, Åsa Annica Kristina Rosenquist

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Abstract

Inhibitors of HCV of formula (I). and the N-oxides, salts, and stereoisomers thereof, wherein the dashed line represents an optional double bond between atoms C7 and C8; R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1-6alkyl; and n is 3, 4, 5, or 6; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I) are provided. Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.

Claims15

Dependent claims

A compound having the formula

and the N-oxides, salts, and stereoisomers thereof, wherein
the dashed line represents an optional double bond between atoms C7 and C8;
R1 is hydrogen or C1-6alkyl;
R2 is hydrogen or C1-6alkyl;
and
n is 3, 4, 5, or 6.

3 more elements

Dependencies are inferred from the claim text.