CCR3 inhibition for ocular angiogenesis and macular degeneration
AssigneeUniversity of Kentucky Research Foundation
InventorJayakrishna Ambati
Life of this patent
Estimating the term…
Abstract
Provided are methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization. Administration of inhibitors of the CCR3 receptor or its ligands eotaxin (CCL11), eotaxin-2 (CCL24) or eotaxin-3 (CCL26) inhibits ocular angiogenesis.
Claims1
A method of diagnosing or monitoring choroidal neovascularization or wet macular degeneration, comprising administering a labeled CCR3-specific binding molecule to a patient and detecting the presence or absence of the labeled CCR3-specific binding molecule in the choroid of the patient, wherein the presence of the labeled CCR3-specific binding molecule being indicative of choroidal neovascularization or wet macular degeneration in said patient.
Dependencies are inferred from the claim text.