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US 8,008,088 B2Granted
SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
AssigneeMasimo Laboratories, Inc.
InventorsEmile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
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Abstract
Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
Claims6
A small molecule metabolite reporter compound of the following formula:
- wherein
- D is a heteroatom other than O;
- R1 and R2 are different and are selected from the group consisting of H, OH, NO2, OCH3, A, or, R1 and R2, taken together with the ring to which they are attached, form R7;
- R3 and R4 are different and are selected from the group consisting of H,
- OH, B(OH)2, M, or R3 and R4 taken together with the ring to which they are attached, form R8;
- R5 and R6 are different and are selected from the group consisting of H or
- wherein Q is H, COOH, or B(OH)2;
- A is OH, or
- R7 is
- R8 is
- M is
- L, when present, is an amino-containing linking moiety;
- R1 and R2, and R3 and R4, are adjacent to each other on the rings on which they reside;
- and
- at least one boronic acid moiety is present;
- and salts thereof.
13 more elements
A small molecule metabolite reporter compound of the following formula:
- wherein R1 and R2 together form R7;
- R3 and R4 are different and are selected from the group consisting of H, B(OH)2, or R3 and R4 taken together with the ring to which they are attached, form R8;
- R6 is selected from the group consisting of H or
- wherein Q is H, COOH, or B(OH)2;
- A is NH3,
- R7 is
- R8 is;
- at least one boronic acid moiety is present;
- and
- R1 and R2, and R3 and R4, are adjacent to each other on the rings on which they reside;
- and salts thereof.
8 more elements
Dependencies are inferred from the claim text.