Production of (R)- and (S)-4-(1-aminoethyl) benzoic acid methyl ester sulfate by lipase acylation of racemic 4-(1-aminoethyl) benzoic acid methyl ester and sulfuric acid precipitation
AssigneeBASF SE
InventorsKlaus Ditrich, Harald Winsel, Dominique Moulin
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Abstract
A method for preparing optically active methyl 4-(1-ammoniumethyl)benzoate sulfate by reacting racemic methyl 4-(1-aminoethyl)benzoate with an acylating agent in the presence of a lipase to give methyl 4-(1-aminoethyl)benzoate and subsequently precipitating methyl 4-(1-ammoniumethyl)benzoate sulfate by adding sulfuric acid.
Claims7
A method for preparing optically active methyl 4-(1-ammoniumethyl)benzoate sulfate comprising reacting racemic methyl 4-(1-aminoethyl)benzoate with an acylating agent in the presence of a lipase to give optically active methyl 4-(1-aminoethyl)benzoate and subsequently precipitating the optically active methyl 4-(1-ammoniumethyl)benzoate sulfate by adding sulfuric acid.
Methyl (S)-4-(1-ammoniumethyl)benzoate sulfate.
Methyl (R)-4-(1-ammoniumethyl)benzoate sulfate.
Dependencies are inferred from the claim text.