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AssigneeRoche Diagnostics Operations, Inc.
InventorsChristopher D. Wilsey, Mitali Ghoshal, Herbert Wieder
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A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.
A chemistry matrix composition for use in determining the concentration of an analyte with reduced interference from other constituents present with the analyte, the matrix comprising glucose dehydrogenase, nicotinamide adenine dinucleotide, a 5-alkylphenazine quaternary salt, and a nitrosoaniline, wherein said matrix is stable at a pH of from about 6.5 to about 8.5 and is photochemically stable.
A chemistry matrix composition for use in analyzing the concentration of an analyte with reduced interference from other constituents present with the analyte, the composition comprising glucose dehydrogenase;
A chemistry matrix composition for use in analyzing the concentration of an analyte, comprising glucose dehydrogenase, nicotinamide adenine dinucleotide, a nitrosoaniline precursor and a photochemically stable 1-carboxyalkyloxy-5-alkylphenazine useful for determining the concentration of an analyte.
Dependencies are inferred from the claim text.