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US 8,008,035 B2Granted
Enhancement of vanadium-containing phosphatase inhibitors
AssigneeRoche Diagnostics Operations, Inc.
InventorsErhard Fernholz, Dorothea Mayr
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Abstract
The present invention is directed to a composition comprising a vanadium-containing phosphatase inhibitor and a polyol. In the presence of the polyol the effect of the inhibitor is enhanced, even in the presence of chelating agents or reducing agents. The invention also concerns the use of the inventive composition for inhibiting a phosphatase, as well as kits comprising the composition.
Claims1
A kit of parts for use with an enzyme having phosphatase activity, the kit comprising packaging material and a composition provided as dry matter, the composition comprising:
- an ionic vanadium-containing inhibitor of phosphatase activity selected from the group consisting of vanadyl (II), vanadate (IV), vanadate (V) and oligomeric vanadate (V);
- a polyol selected from the group consisting of mannitol and glycerol;
- and dithiothreitol,
- wherein the polyol and the inhibitor are present in a molar ratio of between 100:1 and 1:1 (polyol:inhibitor), and wherein the composition provided as dry matter is in the form of a tablet.
1 more element
Dependencies are inferred from the claim text.