Methods of screening for compounds that modulate the activity of ADEC, a chemokine expressed in inflamed adenoid

A method comprising:

• a) combining a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
• 2 with a test compound under conditions permissive for the activity of the polypeptide,
• b) assessing the activity of the polypeptide in the presence of the test compound, wherein the activity comprises chemotactic activities, formation of complexes with neutrophils and/or fibroblasts, and non-chemotactic activation of neutrophils, and
• c) comparing the activity of the polypeptide in the presence of the test compound with the activity of the polypeptide in the absence of the test compound, wherein an increase in the activity of the polypeptide in the presence of the test compound is indicative of a compound that enhances the activity of the polypeptide, and wherein a decrease in the activity of the polypeptide in the presence of the test compound is indicative of a compound that reduces the activity of the polypeptide.