N-terminal truncation of cardiac troponin subunits and their roles in cardiovascular disease
AssigneeEvanston Northwestern Healthcare
InventorJian-Ping Jin
Life of this patent
Estimating the term…
Abstract
Methods for diagnosing, determining the likelihood of developing cardiac disease by measuring the level of a truncated form of cardiac Troponin T are provided. Also provided are methods for preventing treating or ameliorating a symptom associated with cardiac disease by administering a therapeutically effective amount of a modulator of the posttranslational production of N-terminally truncated forms of cardiac troponin T.
Claims15
A method of determining the likelihood of developing or diagnosing a cardiac disease comprising
- (a) obtaining a biological sample of a body fluid from a mammalian subject;
- (b) measuring the level of at least one truncated form of cardiac troponin T in said sample;
- and
- (c) determining the likelihood of developing or diagnosing a cardiac disease based on the measured level of at least one truncated form of cardiac troponin T in said sample.
A method of determining the likelihood of developing or diagnosing a cardiac disease comprising
- (a) obtaining a biological sample of a body fluid from a subject;
- (b) measuring the level of at least one truncated form of cardiac troponin T in the sample resulting from a post-translational truncation of cardiac troponin T;
- and
- (c) determining the likelihood of developing or diagnosing a cardiac disease based on the measured level of at least one truncated form of cardiac troponin T in the sample.
A method of determining the likelihood of developing or diagnosing a cardiac disease comprising
- (a) obtaining a biological sample of a body fluid from a subject;
- (b) measuring the level of at least one truncated form of cardiac troponin T in the sample resulting from a proteolytic truncation of cardiac troponin T;
- and
- (c) determining the likelihood of developing or diagnosing a cardiac disease based on the measured level of at least one truncated form of cardiac troponin T in the sample.
A method of determining the likelihood of developing or diagnosing a cardiac disease comprising
- (a) obtaining a biological sample of a body fluid from a subject;
- (b) measuring the level of at least one truncated form of cardiac troponin T in the sample resulting from NH2-terminal truncation of cardiac troponin T;
- and
- (c) determining the likelihood of developing or diagnosing a cardiac disease based on the measured level of at least one truncated form of cardiac troponin T in the sample.
Dependencies are inferred from the claim text.