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US 8,008,015 B2Granted
Genetic markers of the risk of developing restenosis
AssigneeFina Biotech, S.L.U.
InventorsVicente Andres Garcia, Carlos Silvestre Roig, Patricia Fernandez Ferri, Pedro Luis Sanchez Fernandez, Francisco Fernandez Aviles, Felipe Javier Chaves Martinez
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Abstract
Methods and kits for diagnosing the risk of developing restenosis after revascularization by implantation of stents based on the detection of single-nucleotide polymorphisms (SNPs).
Claims5
Method for determining the risk of a human individual of developing restenosis after implantation of a stent which comprises:
- a) obtaining genomic DNA from a sample of said human individual;
- b) analyzing said sample to determine the genotype of at least one of the single-nucleotide polymorphisms (SNPs) selected from the group consisting of:
- rs350099, rs350104, rs164390 and rs875459, in the CCNB1 gene, c) identifying the presence of a genotype indicative of an increased risk of developing restenosis;
- wherein the presence of a genotype selected from the group consisting of:
- the presence of the TT genotype of rs350099 relative to a human individual that has a CC or CT genotype for this SNP, the presence of the CC genotype of rs350104 relative to a human individual that has a TT or TC genotype for this SNP, the presence of the GG genotype of rs164390 relative to a human individual that has a TT or GT genotype for this SNP and/or the presence of the GG genotype of rs875459 relative to a human individual that has a TT or GT genotype for this SNP, is indicative of an increased risk of developing restenosis;
- and d) determining the risk of said individual of developing restenosis after implantation of a stent.
3 more elements
Dependencies are inferred from the claim text.