Method for storage and perfusion of organs using a solution comprising L-carnitine and isovaleryl L-carnitine
AssigneeSigma-Tau Industrie Farmaceutiche Riunite S.p.A.
InventorsAureli Tommaso, Arduini Arduino
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Abstract
A storage solution to maintain and perfuse organs awaiting transplantation comprising (a) an isotonic balanced solution comprising a physiologically acceptable amount of potassium, mono acidic phosphate, biacidic phosphate, chloride, sodium and bicarbonate ions; (b) 50-250 mM glucose; (c) 0.2-20 mM of an alkanoyl L-carnitine or a physiologically acceptable salt thereof; (d) 1-100 mM of L-carnitine or a physiologically acceptable salt thereof; (e) water is described. The storage solution can also include other components such as anti-oxidants and/or chelating agents.
Claims7
A method of storage for maintaining and perfusing organs awaiting transplantation comprising:
- a) removing the organ from a donor;
- and
- b) placing the removed organ in a isotonic balanced solution comprising:
- i) K2HPO4.3H2O 10-60 mM
- ii) K2HPO4 3-50 mM
- iii) KCL 3-50 mM
- iv) NaHCO3 2-50 mM
- v) glucose 50-250 mM
- vi) isovaleryl L-carnitine 2 mM
- vii) L-carnitine inner salt 10 mM
- water.
Dependencies are inferred from the claim text.