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US 8,007,855 B2Granted
Method for coating implantable medical devices
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorStephen Pacetti
Life of this patent
Estimating the term…
Abstract
A method of coating an implantable medical device is disclosed, the method includes applying a composition onto the device and drying the composition at elevated temperature in an environment having increased relative humidity.
Claims26
A method for coating an implantable medical device, the method comprising:
- (a) applying a polymer composition onto the implantable medical device, the polymer composition comprising a solution of a polymer in a solvent wherein the solvent of the solution comprises a solvent having a boiling point greater than about 120° C. at atmospheric pressure and/or wherein the solvent of the solution comprises a solvent having a vapor pressure less than about 15 Torr at 20° C.;
- and
- (b) drying the polymer composition for a period of time at a drying temperature between 30° C. and 110° C. in an environment having a relative humidity between about 20% and about 100%,
- wherein the polymer is selected from the group consisting of a vinyl polymer, a polyester, and a polysaccharide.
1 more element
A method for coating an implantable medical device, the method comprising:
- (a) applying a coating material comprising a polymer and a solvent to the implantable medical device wherein the solvent of the coating material comprises a solvent having a boiling point greater than about 120° C. at atmospheric pressure and/or wherein the solvent of the coating material comprises a solvent having a vapor pressure less than about 15 Torr at 20° C.;
- and
- (b) drying the coating material in an oven for a period of time at a drying temperature between 30° C. and 110° C., wherein the oven has a relative humidity between about 20% and about 100%,
- wherein the polymer is selected from the group consisting of a vinyl polymer, a polyester, and a polysaccharide.
1 more element
A method for coating an implantable medical device, the method comprising:
- (a) applying a polymer composition onto the implantable medical device, the polymer composition comprising a solution of a polymer in a solvent wherein the solvent of the solution comprises a solvent having a boiling point greater than about 120° C. at atmospheric pressure and/or wherein the solvent of the solution comprises a solvent having a vapor pressure less than about 15 Torr at 20° C.;
- and
- (b) drying the polymer composition for a period of time between about 10 minutes and about 240 minutes at a drying temperature between 30° C. and 110° C. in an environment having a relative humidity between about 20% and about 100%;
- wherein the polymer is a urethane-based polymer.
1 more element
A method for coating an implantable medical device, the method comprising:
- (a) applying a coating material comprising a polymer and a solvent to the implantable medical device wherein the solvent of the coating material comprises a solvent having a boiling point greater than about 120° C. at atmospheric pressure and/or wherein the solvent of the coating material comprises a solvent having a vapor pressure less than about 15 Torr at 20° C.;
- and
- (b) drying the coating material in an oven for a period of time between about 10 minutes and about 240 minutes at a drying temperature between 30° C. and 110° C., wherein the oven has a relative humidity between about 20% and about 100%;
- wherein the polymer is a urethane-based polymer.
1 more element
A method for coating an implantable medical device, the method comprising:
- (a) applying a polymer composition onto the implantable medical device, the polymer composition comprising a solution of a polymer and a therapeutic substance in a solvent wherein the solvent of the solution comprises a solvent having a boiling point greater than about 120° C. at atmospheric pressure and/or wherein the solvent of the solution comprises a solvent having a vapor pressure less than about 15 Torr at 20° C.;
- and
- (b) drying the polymer composition for a period of time at a drying temperature between 30° C. and 110° C. in an environment having a relative humidity between about 20% and about 100%.
A method for coating an implantable medical device, the method comprising:
- (a) applying a polymer composition onto the implantable medical device, the polymer composition comprising a solution of a polymer in a solvent wherein the solvent of the solution comprises a solvent having a boiling point greater than about 120° C. at atmospheric pressure and/or wherein the solvent of the solution comprises a solvent having a vapor pressure less than about 15 Torr at 20° C.;
- and
- (b) drying the polymer composition for a period of time between about 10 minutes and about 240 minutes at a drying temperature between 30° C. and 110° C. in an environment having a relative humidity between about 20% and about 100%.
A method for coating an implantable medical device, the method comprising:
- (a) applying a polymer composition onto the implantable medical device, the polymer composition comprising a solution of a polymer in a solvent wherein the solvent of the solution comprises a solvent having a boiling point greater than about 120° C. at atmospheric pressure and/or wherein the solvent of the solution comprises a solvent having a vapor pressure less than about 15 Torr at 20° C.;
- and
- (b) drying the polymer composition for a period of time at a drying temperature between 30° C. and 110° C. in an environment having a relative humidity between about 20% and about 100%;
- wherein for the solvent in the composition having a boiling point greater than about 120° C. at atmospheric pressure and/or the solvent having a vapor pressure less than about 15 Torr at 20° C., all or most of the solvent removal occurs during the drying operation.
1 more element
Dependencies are inferred from the claim text.