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US 8,007,854 B2Granted
Ceramic coating and method of preparation thereof
AssigneeUniversity of Connecticut
InventorsMei Wei, Haibo Qu, Xiaohua Yu
Life of this patent
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Abstract
A ceramic coating with gradient density/porosity and/or incorporated biologically active agents can be fabricated on the surface of substrates, including the surface of implantable medical devices.
Claims11
A coated substrate, comprising:
- a gradient ceramic coating, wherein the gradient ceramic coating is prepared by exposing a portion of a substrate to an aqueous system, wherein the exposing is performed at a temperature of about 20° C. to about 100° C.;
- wherein the aqueous system comprises water, Ca2+, Mg2+, Na+, K+, Cl—, SO42-, HPO42-, HCO3- and a buffer system;
- and
- wherein the aqueous system has an initial pH of about 5.5 to about 7.5;
- and
- the gradient ceramic coating has a density of about 75 to about 90% closest to the substrate and a density of about 35 to about 60% at the gradient ceramic coating surface as determined by scanning electron microscope.
3 more elements
A coated substrate, comprising:
- a ceramic coating comprising a biologically active agent, wherein the ceramic coating is prepared by exposing a portion of a substrate to an aqueous system, wherein the exposing is performed at a temperature of about 20° C. to about 100° C.;
- wherein the aqueous system comprises water, Ca2+, Mg2+, Na+, K+, Cl—, SO42-, HPO42-, HCO3-, a buffer system and a biologically active agent;
- and
- wherein the aqueous system has an initial pH of about 5.5 to about 7.5,
- wherein during the exposing, a ratio of aqueous system volume to substrate surface area is about 1 mm to about 50 mm.
2 more elements
Dependencies are inferred from the claim text.