Granule formation
AssigneeMerck Frosst Canada, Inc.
InventorBrian Down
Life of this patent
Estimating the term…
Abstract
The present invention relates to oral granules of montelukast sodium.
Claims5
A flowable and dispersible pharmaceutical composition which comprises (i) granules comprising a pharmaceutically acceptable substrate which is spray-dried mannitol agglomerated with a pharmaceutically acceptable binder, and coated with montelukast sodium, and (ii) a pharmaceutically acceptable lubricant;
- wherein said binder is selected from hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose, ethylcellulose and polyvinylpyrrolidone;
- and said granules are formed by coating said substrate with an aqueous solution consisting of montelukast sodium followed by drying.
A flowable and dispersible pharmaceutical composition which comprises (i) granules comprising a pharmaceutically acceptable substrate which is spray-dried mannitol agglomerated with hydroxypropyl cellulose, said substrate being coated with montelukast sodium, and (ii) magnesium stearate, and said granules are formed by coating said substrate with an aqueous solution consisting of montelukast sodium followed by drying.
Dependencies are inferred from the claim text.