Pharmaceutical dosage forms having immediate release and/or controlled release properties
AssigneeImpax Laboratories, LLC
InventorsChien-Hsuan Han, Larry Hsu, Ann F. Hsu
Life of this patent
Estimating the term…
Abstract
The present invention relates generally to pharmaceutical dosage forms comprising: an absorption window active agent; a controlled release component comprising enteric-coated controlled release beads, wherein the enteric-coated release beads comprise at least two pH-sensitive polymer layers. The controlled-release dosage forms provide good bioavailability of absorption window active agents.
Claims45
A pharmaceutical dosage form of an absorption window active agent selected from the group consisting of baclofen, gabapentin, levodopa, α-methyldopa, valacyclovir, or a mixture of any thereof that exhibits prolonged absorption of the active agent in the small intestine comprising a plurality of controlled release particles, each particle comprising:
- i. the absorption window active agent selected from the group consisting of baclofen, gabapentin, levodopa, α-methyldopa, valacyclovir, or a mixture of any thereof;
- ii. an inner pH-sensitive polymer layer substantially enveloping the absorption window active agent;
- and
- iii. an outer pH-sensitive polymer layer substantially enveloping the absorption window active agent and inner pH-sensitive layer;
- wherein the dosage form provides prolonged absorption of the absorption window active agent in the small intestine, and wherein the outer pH-sensitive polymer layer dissolves at a lower pH than the inner pH-sensitive polymer layer.
Dependencies are inferred from the claim text.