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US 8,007,821 B2Granted
Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with microstructured surface
AssigneeCeloNova BioSciences Germany GmbH
InventorMichael Grunze
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Abstract
The invention relates to substrates containing polyphosphazene with a forming surface as matrices for producing biological materials that can be implanted in a mammal. The invention also relates to a method for producing said substrates and substrates containing polyphosphazene with a microstructured surface.
Claims12
A method for producing an implantable biological material, the method comprising:
- providing a form-building surface of a substrate;
- disposing a polymer of general formula (I) to form a biocompatible coating layer, at least partially, above the form-building surface of the substrate;
- contacting donor cells of a biological starting material with the biocompatible coating layer to promote the formation of cellular aggregations of the biological starting material above the biocompatible coating layer;
- and
- detaching in vitro the cellular aggregations of the biological starting material from the biocompatible coating layer to produce the implantable biological material,
- wherein the general formula (I) is
- wherein n is 2 to ∞, and
- wherein R1 to R6 are the same or different and represent a group selected from the group consisting of an alkoxy, an alkylsulfonyl, a dialkylamino, an aryloxy, a heterocycloalkyl having nitrogen as a heteroatom, and a heteroaryl having nitrogen as a heteroatom.
5 more elements
Dependencies are inferred from the claim text.