Composition and method for facilitating the internalization of a therapeutic agent into a cell
AssigneeThe Board of Trustees of the Univeristy of Illinois
InventorsRomana A. Nowak, Robert J. Belton, Jr.
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Abstract
The present invention is a composition and method for facilitating the internalization of a therapeutic agent into a cell. Specifically, the invention relates to the use of the extracellular domain of basigin-2, cyclophilin, or anti-basigin-2 antibody or antibody fragment as a delivery moiety for internalization of a therape.
Claims2
A composition for facilitating the internalization of a therapeutic agent into a cell, comprising a delivery moiety operably linked to a therapeutic agent, wherein the delivery moiety is the extracellular domain of basigin-2, wherein the basigin-2 is not glycosylated;
- and the therapeutic agent comprises an anti-inflammatory protein, anti-viral, anti-parasitic, anti-bacterial, endocrine drug, metabolic drug, mitotoxin, chemotherapy drug, or siRNA.
A composition for facilitating the internalization of a therapeutic agent into a cell, comprising a delivery moiety operably linked to a therapeutic agent, wherein the delivery moiety is the extracellular domain of basigin-2, wherein the extracellular domain of basigin-2 comprises SEQ ID NO:13;
- and the therapeutic agent comprises an anti-inflammatory protein, anti-viral, anti-parasitic, anti-bacterial, endocrine drug, metabolic drug, mitotoxin, chemotherapy drug, or siRNA.
Dependencies are inferred from the claim text.