Means and methods for the treatment of tumorous diseases

A method for the treatment or amelioration of indolent or aggressive B cell non-Hodgkin lymphoma (B NHL) or B cell leukemia, the method comprising the administration of a pharmaceutical composition comprising a bispecific single chain antibody construct to a subject in the need thereof, said bispecific single chain antibody construct comprising binding domains specific for human CD3 and human CD19, wherein the corresponding variable heavy chain regions (VH) and the corresponding variable light chain regions (VL) regions are arranged, from N-terminus to C-terminus, in the order,

• VL(CD19)-VH(CD19)-VH(CD3)-VL(CD3),
• VH(CD19)-VL(CD19)-VH(CD3)-VL(CD3),
• VH(CD3)-VL(CD3)-VH(CD19)-VL(CD19) or
• VH(CD3)-VL(CD3)-VL(CD19)-VH(CD19),
• wherein the bispecific single chain antibody construct is administered for at least 1 week in a daily dose of 10 μg to 80 μg per square meter patient body surface area and wherein the daily dose is administered over at least 6 h,
• and wherein each VL and VH region comprises a CDR1, CDR2, and CDR3 region.