Antagonist antibodies directed against calcitonin gene-related peptide and methods using same

An isolated antibody comprising

• a. CDR H1 as set forth in SEQ ID NO:
• 3:
• b. CDR H2 as set forth in SEQ ID NO:
• 4, or variants as shown in Table 6;
• c. CDR H3 as set forth in SEQ ID NO:
• 5:
• d. CDR L1 as set forth in SEQ ID NO:
• 6, or variants as shown in Table 6;
• e. CDR L2 as set forth in SEQ ID NO:
• 7, or variants as shown in Table 6;
• and
• f. CDR L3 as set forth in SEQ ID NO:
• 8;
• wherein the antibody has a binding affinity (KD) to human α-CGRP of 50 nM or less as measured by surface plasmon resonance at 37° C.