Prevention and treatment of complement-associated eye conditions

A method for the treatment of a complement-associated eye condition comprising administering to a subject in need an effective amount of a Factor D antibody or a binding fragment thereof, wherein said antibody or binding fragment comprises the Complementarity Determining Regions (CDRs) of antibody 20D12 light and heavy chains (SEQ ID NOS:

• 1 and 2, respectively), and wherein the light chain CDR1 sequence comprises amino acid residues 24-34, the light chain CDR2 sequence comprises amino acid residues 50-56, the light chain CDR3 sequence comprises amino acid residues 89-97 of SEQ ID NO:1, and the heavy chain CDR1 sequence comprises amino acid residues 31-35, the heavy chain CDR2 sequence comprises amino acid residues 50-65, and the heavy chain CDR3 sequence comprises amino acid residues 95-102 of SEQ ID NO:2.