Antigenic modulation of cells

A non-aggregating, non-immunogenic anuclear cellular composition consisting of:

• a) a mammalian anuclear cell having a cell surface and antigenic determinants on said surface;
• a sufficient amount of hydrophilic, biocompatible, non-immunogenicity providing compound or polymer covalently attached to said surface so that recognition of said antigenic determinants on said surface is blocked by said covalently bonded hydrophilic, biocompatible, non-immunogenicity providing compound or polymer wherein linking moieties are covalently bonded to said antigenic determinants on said cell surface.

A non-aggregating, non-immunogenic anuclear cellular composition consisting of:

• a) a mammalian anuclear cell having a cell surface and antigenic determinants on said surface;
• a sufficient amount of hydrophilic, biocompatible, non-immunogenicity providing compound or polymer covalently attached to said surface so that recognition of said antigenic determinants on said surface is blocked by said covalently bonded hydrophilic, biocompatible, non-immunogenicity providing compound or polymer wherein said cell is an anuclear cell and the covalently bonded hydrophilic, biocompatible, non-immunogenicity providing compound or polymer is covalently bonded to the nuclear cell through a unit derived from reaction of a cyanuric chloride linking group on the covalently bonded hydrophilic, biocompatible, non-immunogenicity providing compound or polymer to the cell surface.

A non-aggregating, non-immunogenic anuclear cellular composition consisting of:

• b) a mammalian anuclear cell having a cell surface and antigenic determinants on said surface;
• a sufficient amount of hydrophilic, biocompatible, non-immunogenicity providing compound or polymer covalently attached to said surface so that recognition of said antigenic determinants on said surface is blocked by said covalently bonded hydrophilic, biocompatible, non-immunogenicity providing compound or polymer wherein said cell is a platelet and the covalently bonded hydrophilic, biocompatible, non-immunogenicity providing compound or polymer is covalently bonded to the nuclear cell through a unit derived from reaction of a cyanuric chloride linking group on the covalently bonded hydrophilic, biocompatible, non-immunogenicity providing compound or polymer to the cell surface.

A method of producing a non-immunogenic mammalian cell, said method comprising:

• covalently attaching an amount of hydrophilic, biocompatible, non-immunogenicity providing compound or polymer to the cell surface, directly or by means of a linking moiety, so that said hydrophilic, biocompatible, nonimmunogenicity providing compound or polymer blocks recognition of antigenic determinants on the cell surface and yields a non-immunogenic cell wherein linking moieties covalently attach the hydrophilic, biocompatible, non-immunogenicity providing compound or polymer to said surface, said linking moiety is covalently bonded to said antigenic determinants on said cell surface.