Use of calcium binding proteins to improve cardiac contractile function
AssigneeThe Regents of the University of California
InventorsWolfgang H. Dillmann, Jorge Suarez, Darrell Belke, Bernd Gloss
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Abstract
Methods useful in the regulation of myocardial contraction are disclosed. The methods are useful in the regulation of heart function. The invention reveals that sorcin overexpression enhances cardiac contractile performance and establishes the concept of sorcin as a regulator of myocardial contractility. The invention also provides screening assays that allow for the identification of agents that modulate sorcin expression. Such agents are useful, for example, for diagnosing cardiac contractile function associated disorders in subjects, and treating the subjects with the agents identified as being able to modulate sorcin expression.
Claims10
A method of increasing cardiac contractile function in a subject comprising altering the expression of sorcin in the subject's heart by administering a viral vector encoding sorcin to the subject, wherein sorcin expression and contractile function are increased as compared to sorcin expression and contractile function prior to administration.
A method of treating heart failure, comprising administering an adenoviral or adeno-associated virus vector encoding sorcin to a subject, wherein sorcin expression and contractile function are increased as compared to sorcin expression and contractile function prior to administration.
A method for monitoring a therapeutic regimen for treating a subject having heart failure, comprising determining a change in sorcin expression during therapy.
Dependencies are inferred from the claim text.