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US 8,007,769 B2Granted
Method for diagnosing an increased risk of preeclampsia by measuring the level of HIF-α
AssigneeMount Sinai Hospital
InventorsIsabella Caniggia, Martin Post, Stephen Lye
Life of this patent
Estimating the term…
Abstract
Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-β3, receptors of cytokines of the TGβ family, or HIF-1α.
Claims22
A method for diagnosing an increased risk of preeclampsia in a subject, the method comprising
- a) detecting a level of HIF-1α in a fluid sample from the subject;
- and
- b) comparing the level detected in the subject's fluid sample to a control level obtained from samples of the same fluid taken at the same time of pregnancy from women who did not develop preeclampsia;
- wherein an increased level of HIF-1α in the fluid sample from the subject over that of a control level obtained from samples of the same fluid taken at the same time of pregnancy from women who did not develop preeclampsia indicates an increased risk of preeclampsia.
1 more element
A method for diagnosing or identifying an increased risk of preeclampsia in a subject, the method comprising:
- a) contacting a fluid sample from a subject at a first time in pregnancy with a diagnostic reagent that measures a first level of HIF-1α;
- and
- b) diagnosing or identifying an increased risk of preeclampsia in the subject based upon an increased level of HIF-1α in the fluid sample from the subject over that of
- (i) a first control level of HIF-1α obtained from samples of the same fluid taken at the same time of pregnancy from women who did not develop preeclampsia;
- or
- (ii) an earlier sample level of HIF-1α obtained from samples of the same fluid taken from the same subject at an earlier time in the pregnancy.
3 more elements
A method for diagnosing or identifying an increased risk of preeclampsia in a subject, the method comprising:
- a) detecting a level of HIF-1α in a fluid sample from the subject in the first 16 weeks of pregnancy;
- and
- b) comparing the level detected in the subject's fluid sample to a control level obtained from samples of the same fluid taken at the same stage of pregnancy from women who did not develop preeclampsia;
- wherein an increased level of HIF-1α in the fluid sample from the subject indicates the increased risk of preeclampsia.
1 more element
Dependencies are inferred from the claim text.