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US 8,007,737 B2Granted
Use of antioxidants to prevent oxidation and reduce drug degradation in drug eluting medical devices
AssigneeWyeth
InventorRoy R. Fennimore, Jr.
Life of this patent
Estimating the term…
Abstract
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. In each of these instances, antioxidants are utilized to prolong product integrity.
Claims3
A drug eluting medical device comprising:
- an implantable intraluminal structure;
- a first polymeric solution;
- a drug in therapeutic dosages, incorporated into the first polymeric solution creating a resulting mixture;
- a separate and distinct antioxidant incorporated into the resulting mixture to substantially hinder degradation of the drug through oxidation, thereby creating a base coat with the antioxidant mixed or comingled with the drug in the base coat, the base coat being affixed to at least a portion of the implantable intraluminal structure;
- and
- a second polymeric solution forming a top coat affixed to the base coat.
3 more elements
Dependencies are inferred from the claim text.