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AssigneeInstitute of Nuclear Energy Research
InventorsMing-Hsin Li, Hsin-EII Wang, Chun-Yi Wu, Wuu-Jyh Lin
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An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.
An automatic synthesis device for fluorine-18-ACETATE comprising:
Dependencies are inferred from the claim text.
From the US filing history. Foreign family members aren’t listed.
No references of this kind are recorded.
Controlling or regulating processes: multifunctional apparatus for automatic manufacturing of various chemical products
Chemical or physical processes
About 3 years 4 months of term left · ends 3 Mar 2030 (estimated)
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1. Field of the Invention
The invention is related to an automatic synthesis device to produce fluorine-18-ACETATE that is suitable for brain tomography in nuclear medicine. Especially it refers to a synthesis device for man-made radioactive isotope with easy operation and good production efficiency.
2. Description of the Prior Art
FIG. 1 shows the block diagram for the entire structure and pipeline configuration for the invention.
FIG. 2 is the front view for the assembly of the invention.
FIG. 3 is the rear view for the assembly of the invention.
Please refer to the figures from FIG. 1 to FIG. 3. It can be clearly found that the structure for the invention mainly consists of a machinery housing 1 that has an accommodating space 1a and at least an open display section 1b on one side of the machinery housing 1;
and multiple raw material containers B1˜B9 located in the display section 1b of the machinery housing 1 with the raw material container B1 holding TBAHCO3, the raw material container B3 holding precursor, the raw material container B4 holding dichloromethane, the raw material container B5 holding acetone, the raw material container B6 holding alcohol, the raw material container B7 holding water, the raw material container B8 holding sodium hydroxide and the raw material container B9 holding hydrochloric acid; and two reactors G3, G4 in the accommodating space 1a of the machinery housing 1 that connect to the above-mentioned raw material containers B1˜B9 through pipelines and are integrated with heating apparatus 31, 41, and between the two reactors G3, G4, a silicone column 5 allowing the two reactors G3, G4 to connect to two injectors 3, 4, with the injector 3 being able to inject the reaction intermediate from the reactor G3 into the silicone column 5 for separation and then introducing it into reactor G4, while injector 4 being able to introduce the finished product from reactor 4 into a sterile collection container for finished product G5; and another two collection containers G1, G2 located in the accommodating space 1a of the machinery housing 1 and being filled in advance with oxygen-18 water containing [18F]HF and connecting to reactor G3 through pipelines.
A multiple number of control valves V1˜V27 are located on the pipelines (distribution diagram as shown in FIG. 1). V1, V2, V4 and V14 are three-way solenoid valves. V3, V5˜V13 and V15˜V26 are normal-close solenoid valves. Flow control valve V27 is a needle valve to control helium flow. Overall, the valves are to control the flow of raw material gas and vacuum and facilitate each raw material to undergo synthesis reaction in the reactors G3, G4. Between three-way solenoid valves V1, V2, there is a QMA ion exchange column 2. Besides, in the accommodating space 1a there is a pressure regulating valve 7 to regulate helium gas pressure and a valve block 8 to distribute compressed air. On the lower side of the two reactors G3, G4 there is a lead shielding 6, 61 containing Geiger tube for each one to monitor the radiation strength signal during the reaction process.