Medicated porous metal prosthesis
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorJohn Y. Yan
Life of this patent
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Abstract
A porous prosthesis for delivering a medication to the site of implantation. The prosthesis, such as a stent, includes a first porous region and a second porous region and is at least partially formed from a molybdenum-rhenium alloy. The porous regions can have different porosity. A stent includes first, second and third porous region, the first porous region being between the second and third porous regions, and a therapeutic agent is disposed in the first porous region. A stent can also include a solid core and inner and outer porous layers surrounding the core.
Claims11
A stent comprising:
- a body substantially formed of a molybdenum-rhenium alloy including an interconnected network of struts,
- wherein the struts include a metallic core formed by large diameter particles defining a first porous region, and a second porous region and a third porous region formed by smaller diameter particles, such that the first porous region is disposed between the second porous region and third porous region and the average pore size of the first porous region is greater than the average pore size of the second porous region and the average pore size of the third porous region.
A stent comprising a strut element, the strut element being at least partially formed of a molybdenum-rhenium alloy,
- wherein the strut element includes a solid metallic inner core having an inner side and an opposed, outer side,
- an outer layer disposed on the outer side, the outer layer being a first porous layer of metallic material formed by particles, filaments or fibers sintered to the inner core, and
- an inner layer disposed on the inner side, the inner layer being a second porous layer of metallic material formed by particles, filaments or fibers sintered to the inner core,
- wherein the strut is formed from a metallic sheet such that the solid core causes a therapeutic agent loaded into the second porous layer to flow only in a radially inward direction after the stent has been implanted in a vessel, and
- wherein the stent is configured for being radially expanded by a balloon and for providing support to a body vessel after the stent has been radially expanded by the balloon.
A stent comprising:
- a body at least partially formed of a molybdenum-rhenium alloy including an interconnected network of struts,
- wherein the struts include a first porous metallic layer, a second porous metallic layer, and a metallic core, and
- the first and second layers are located on opposite sides of the metallic core,
- the first porous layer is formed from particles having a first diameter, thereby forming a first average pore size,
- the second porous layer is formed from particles having a second diameter, thereby forming a second average pore size, and
- the first average pore size is greater than the second average pore size.
A stent comprising:
- a body substantially formed of a molybdenum-rhenium alloy including an interconnected network of struts,
- wherein the struts include a second porous region, a third porous region, and a first porous region disposed between the second porous region and third porous region,
- wherein the average pore size of the first porous region is greater than the average pore size of the second porous region and the average pore size of the third porous region, and
- wherein the stent has a therapeutic agent loaded into the first porous region, and
- wherein the first porous region is devoid of a polymer layer for purposes of delivering therapeutic agents.
Dependencies are inferred from the claim text.