Method of therapeutically treating tissue while preventing perfusion/ventilation of the tissue

A method of treating a tissue region, comprising:

• introducing a delivery sheath within an anatomical conduit, the delivery sheath comprising a pullwire extending proximally from a distal end of the delivery sheath;
• expanding an occlusive device associated with the delivery sheath, such that the conduit is at least partially occluded to reduce the flow of fluid through the conduit;
• manipulating a proximal end of the pullwire so as to bend the distal end of the delivery sheath so that the distal end is pointing towards a puncture site of the conduit adjacent the tissue region;
• introducing a tissue treatment catheter within the delivery sheath, the tissue treatment catheter having a lumen therein;
• advancing a scope within the lumen of the tissue treatment catheter to visualize the tissue region;
• removing the scope from the lumen of the tissue treatment catheter;
• introducing a stylet within the lumen of the tissue treatment catheter;
• piercing the conduit wall to create an aperture in the wall of the conduit adjacent the tissue region;
• advancing the tissue treatment catheter from the delivery sheath over the stylet and through the aperture;
• and
• conveying thermal energy from or to the tissue treatment catheter to treat the tissue region.