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US 8,003,680 B2Granted
Therapeutic compounds
AssigneeAllergan, Inc.
InventorsDavid W. Old, Vinh X. Ngo
Life of this patent
Estimating the term…
Abstract
Disclosed herein are compounds of the formula therapeutic methods, compositions, and medicaments related thereto are also disclosed.
Claims21
A compound of the structure
- or a pharmaceutically acceptable salt thereof, or a prodrug thereof;
- wherein a dashed line represents the presence or absence of a bond;
- Y is an organic acid functional group, or an amide or ester thereof consisting of up to 14 carbon atoms;
- or Y is hydroxymethyl or an ether thereof consisting of up to 14 carbon atoms;
- or Y is a tetrazolyl functional group;
- A is —(CH2)m—Ar—(CH2)o— wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein one CH2 may be replaced by S or O;
- U1 is independently hydrogen;
- OH;
- O;
- S;
- F;
- Cl;
- Br;
- I;
- CN;
- or O-alkyl consisting of 1, 2, 3, 4, 5 or 6 carbon atoms;
- J1 and J2 are independently hydrogen;
- F;
- Cl, Br;
- I;
- O;
- OH;
- CN;
- O-alkyl consisting of 1, 2, 3, 4, 5 or 6 carbon atoms;
- alkyl consisting of 1, 2, 3, 4, 5, or 6 carbon atoms;
- or CF3;
- Z is S, SO, SO2, NR, NCOR, or NSO2R, wherein R is H or C1-6 hydrocarbyl, and
- B is aryl or heteroaryl.
25 more elements
A compound which is a carboxylic acid or a bioisostere thereof, said carboxylic acid having a structure
- or a pharmaceutically acceptable salt thereof, or a prodrug thereof;
- wherein a dashed line represents the presence or absence of a bond;
- A is —(CH2)m—Ar—(CH2)o— wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein one CH2 may be replaced by S or O;
- U1 is independently hydrogen;
- OH;
- O;
- S;
- F;
- Cl;
- Br;
- I;
- CN;
- or O-alkyl consisting of 1, 2, 3, 4, 5 or 6 carbon atoms;
- J1 and J2 are independently hydrogen;
- F;
- Cl, Br;
- I;
- O;
- OH;
- CN;
- O-alkyl consisting of 1, 2, 3, 4, 5 or 6 carbon atoms;
- alkyl consisting of 1, 2, 3, 4, 5, or 6 carbon atoms;
- or CF3;
- Z is S, SO, SO2, NR, NCOR, or NSO2R, wherein R is H or C1-6 hydrocarbyl, and
- B is aryl or heteroaryl.
22 more elements
Dependencies are inferred from the claim text.